99951 avhandlingar från svenska högskolor och universitet. Avhandling: Helicobacter pylori Sialic Acid-Specific Surface Lectin.

Abstract. Vibrio cholerae neuraminidase (VCNA) plays a significant role in the pathogenesis of cholera by removing sialic acid from higher order gangliosides to unmask GM1, the receptor for cholera toxin. We previously showed that the structure of VCNA is composed of a central beta-propeller catalytic domain flanked by two lectin-like domains;

To date, most studies of SBLs were performed in animal adhesion molecules Siglecs [8], which are expressed on the cell Lectins; Sialic Acid 8 Product Results . View as List Grid. Sort By. Set Descending Direction. Show. per page. Sambucus Nigra Lectin (SNA, EBL), CY®5 2010-01-01 · Influenza virus A is the most well-known and best-studied example in the field.

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They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. Several recently discovered mammalian cell adhesion proteins recognize and bind to sialic acid-containing ligands. Reports concerning the molecular specificities of these interactions have been intriguing but somewhat confusing, partly because of pitfalls in methodology or interpretation. Sialic acid can "hide" mannose antigens on the surface of host cells or bacteria from mannose-binding lectin.

The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids.

1998-6-23

Here, we clarified its sialic acid‐binding mechanism using NMR spectroscopy. lectin with a broad range of sialic acid analogs and with glycoproteins containing sialic acid in different oligosaccha- ride chains. As there are sialic acid-specific lectins that inter- act also with other sugars (13, 16), we intended to clarify this point for Cepaea lectin.

There are several sialic acid-binding lectin families, such as the sialic acid-binding immunoglobulin-like lectins (siglecs) and selectins. This study shows that SBP is a sialic acid binding lectin that belongs to the Hsp family, a Hsp-like lectin. Therefore, Hsp-like lectin can be regarded as a new member of the sialic acid-binding lectin

Target-specific ELISA kits are available from a variety of manufacturers … Sialic Acid-Binding Lectin Polyclonal Antibody, Biotin Conjugated. Biotin.

Enzyme-linked immunosorbent assay for Antigen Detection.
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Sialic acid‐binding immunoglobulin‐like lectin‐7 (Siglec‐7) is an immunomodulatory molecule expressed on various immune cells, including macrophages, which plays a key role in liver inflammation and fibrosis in NAFLD. Likewise, colominic acid, a homopolymer [poly-α-(2,8)-NANA], had no inhibitory effect at the concentration of 10 mg/ml, indicating that the lectin had less affinity towards subterminal sialic acid than terminal residues. 2021-02-24 · The literature contains several reviews on lectins in general, covering mainly those from plants and invertebrates. However, the sialic acid binding lectins have not been reviewed so far.

Sialic acid-binding immunoglobulin (Ig)-like lectins (siglecs) are a family of type I membrane proteins containing a homologous N-terminal V-set Ig-like domain that binds sialylated glycoconjugates and various numbers of C2-set Ig-like domains .
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Sialic acid-dependent binding of Siglec-9 was confirmed using neuraminidase as shown in Fig. 1B. To examine the effects of the interaction between immune cells and cancer cells via Siglec-9 on the signaling pathway in both sides of cells, co-culture experiments with U937 and AS cells were performed.

Senast uppdaterad: 2014-12-09. Användningsfrekvens: 4. Kvalitet: Bli den första att rösta. Referens: Wikipedia (elisa) och enzyme-linked lectin assay (ella). avhandlingens studier.

SIGLECs, such as SIGLEC14, are single-pass transmembrane sialic acid-binding immunoglobulin (Ig)-like lectins found mainly on leukocytes. SIGLEC14 belongs to the rapidly evolving CD33 (159590)-related SIGLEC subfamily, which includes SIGLEC5 (604200).

SIGLEC (sialic acid binding Ig-like lectin) Entry whose protein (s) existence is based on evidence at protein level. TY - THES. T1 - Helicobacter pylori Sialic Acid-Specific Surface Lectin. AU - Hirmo, Siiri. N1 - Defence details Date: 2000-05-04 Time: 10:15 Place: Rune Grubb salen, BMC, Sölvegatan 19, Lund External reviewer(s) Name: Feizi, Ten Title: Prof Affiliation: Imperial College School of Medicine, Northwick Park Institute for Medical Research, Watford Road, Harrow, U.K. --- 2021-03-02 · sialic acid-binding Ig-like lectin 10, sialic acid binding Ig-like lectin 10 Ig-like lectin 7, siglec-like gene 2, siglec-like protein 2 GeneRIFs: Gene References Into Functions Siglec-10 expression is up-regulated in activated human CD4(+) T cells.

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